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"Hacking Heroin" was the first hackathon that Annie Rittgers, founder of Cincinnati-based 17a, had organized or even attended. "There will continue to be a lot of preventable overdose deaths and wasted potential if the opioid crisis continues unabated," she said. "Bright spots and positive momentum matter when it comes to directing the energy that exists in Cincinnati toward addressing the epidemic." Now though, days before Hacking Heroin in June 2017, it wasn't clear that Rittgers's intercession would prove to be one of these "bright spots." Not quite 50 people had registered for the free event, and there was no guarantee that they would attend. Sponsorships for the event had been slow to materialize. The eight challenges that she and the team planned to pose to hackathon participants were mostly, but not entirely, settled. Some, but not all, of the key hospital leaders had signed on to participate in the event. Rittgers wondered what she could do to nudge the hackathon towards success. Were these just expected hurdles, and it would all turn out okay? Were they warning signs that warranted remedy? Or were they cues that hackathon skeptics had been right all along-what kind of way was this to address a problem of epidemic proportions anyway?

Over the past several decades, rapid growth in Chinese investment and trade has created for Africa a new development partner. China represents an alternative to U.S. and European nations whose past imperialism, resource avarice, and economic dictates-through the conditionality of IMF and World Bank lending-remain a negative legacy. This case uses the story of Zambia's Chambishi copper mine, which was purchased in 1998 by the state-owned China Non-Ferrous Metals Mining Corporation, to illustrate China's growing interest and involvement in the African continent. While many in Africa welcome the substantial Chinese investment, resentment over labor abuses, low pay, and substandard working conditions at some Chinese-owned enterprises fuels anti-China sentiment. At Chambishi copper mine, a 2005 explosion, caused by management's shoddy adherence to safety standards, killed nearly 50 miners and sparked outrage among Zambians. The explosion marked the first in a long series of protests and safety violations that would unfold at Chambishi over the next ten years.

In January 2016, Guillermo Jaime had just returned home to Mexico City after attending a Harvard Business School executive education program. Jaime was the founder and CEO of Mejoramiento Integral Asistido (MIA), a company providing affordable housing to low-income Mexicans living at the base of the pyramid (BOP), defined as those living on less than $10 per day. Since its launch in 2009, MIA had built nearly 25,000 homes-which provided safe shelter to more than 100,000 Mexicans-while generating an earnings before interest, taxes, depreciation, and amortization (EBITDA) margin of over 8%. At the executive education program, Jaime had learned that entrepreneurs could build on their unique attributes and capabilities to expand and grow their businesses. Should he continue to expand the services MIA offered to BOP customers? Could he leverage what made MIA unique-offering affordable homes for its BOP customers in Mexico-to fulfill other critical needs at the BOP for water, clean energy, and health care services? Jaime was an expert in housing, but could he translate that expertise to such diverse sectors? If so, how should he begin?

Guillermo Jaime was the founder and CEO of Mejoramiento Integral Asistido (MIA), a for-profit company providing affordable housing to low-income Mexicans living at the base of the pyramid (BOP). This case tells the story of Jaime and Endeavor, a non-profit dedicated to leading the high impact entrepreneurship movement as a tool for economic development in countries around the world. In 2010, Jaime was named an Endeavor Entrepreneur. This case can accompany HBS Case Study "MIA: Profit at the Base of the Pyramid," No. 817073.

Luminopia-a start-up founded in January 2016 by three Harvard College freshmen-uses virtual reality technology to treat amblyopia (more commonly called "lazy eye"), the single biggest cause of visual disorders among children. By February 2017, the three founders had raised $950,000 in angel funding and developed a prototype of their virtual reality product, which was in use in clinical trials at Boston Children's Hospital. As the founders prepare to bring their new medical device to market, they struggle with two key decisions: Should Luminopia create its own salesforce to sell its product or should it outsource? And how should the company price its device to maximize returns yet remain attractive to doctors, insurance providers, and individual patients?

The U.S. Patent and Trademark Office (USPTO) is the federal government agency responsible for evaluating and granting patent and trademark applications. In 2015, the USPTO employed approximately 8,000 patent examiners who granted nearly 300,000 patents to inventors. As of April 2016, it took roughly 26 months for a patent application to move through the evaluation process, which exceeded the office's processing goal of 20 months. In August 2016, Andrew Hirshfeld, the commissioner for patents at the USPTO, considered the current state of patent examination and future possibilities. In recent years, a number of new and exciting tools enabled by advances in telework, machine learning, and other approaches had emerged. Hirshfeld hoped to maximize these tools' utility in order to enhance patent examiners' work and productivity. Helping examiners become more productive could in turn help the USPTO achieve its joint goals of processing patent applications more quickly and granting better quality patents. But the new tools and organizational changes would bring challenges too. Any changes would have to be implemented at the grassroots of the USPTO organization, and ongoing pilots would not be successful without the buy-in and cooperation of both individual examiners as well as the union.

This note describes virtual reality and augmented reality technologies, and describes the main consumer products on offer in 2016 and their manufacturers. It also surveys existing applications of virtual and augment reality technologies.

In 2019, Fitbit lost its leadership in the wearable sensor market to Apple and to cheaper alternatives. Why did it lose its market position? How will the proposed acquisition affect it and Google?

In 2013, Sam Frons founded Addicaid-a mobile application (app) that allowed people in addiction recovery to track their progress, check in with counselors, and connect with others in recovery programs. The app was grounded in cognitive behavioral therapy and used the rich set of data it collected from users to suggest tailored coping mechanisms for avoiding relapse. In September 2016, six months after quitting her full-time job to focus solely on Addicaid, Frons struggled to transition what was once a passion project into a full-fledged business. Two weeks earlier, Frons had approached a private, for-profit chain of addiction treatment centers about offering the app to its clients as a support tool for the recovery process once they completed treatment. The chain's management team was interested, but wanted more information about how Addicaid could help it reach its target bed occupancy rate. A recovering addict herself, Frons founded Addicaid in 2013 to help people with substance abuse problems and process disorders (such as food, gambling, internet, pornography, and sex addictions) reach their goals-which presumably included staying out of treatment centers. But now Addicaid needed to establish a business model that also created value for treatment centers. How should Frons address this inherent tension? What path should she pursue to scale her company into a sustainable, revenue generating business?

Founded in 2014, Carrum Health helped self-insured employers located in three markets (San Diego, California; Seattle, Washington; and San Francisco, California) save money on their employees' planned surgeries. It did so by contracting directly with top-quality hospitals located within the area, and negotiating a set fee (known as a bundled payment) for each of five common surgical procedures: knee replacement, hip replacement, cervical spinal fusion, lumbar spinal fusion, and coronary bypass. By 2016, the company was growing steadily and saving its clients over 40% on average on these five procedures. In September 2016, Sachin Jain, Carrum's CEO, received an email from North Beach Apparel, a large retailer based in San Francisco with a growing presence near Chicago, Illinois and Columbus, Ohio. North Beach was ready to partner with Carrum, but the terms of the deal required Carrum to enter the Chicago and Columbus markets in order to serve all North Beach employees. The deal would significantly increase Carrum's revenue and begin to move the entrepreneurial venture closer to profitability. However, by expanding to Chicago and Columbus, the young company ran the risk of spreading itself too thin, especially given the opportunity for growth in Carrum's current three markets. But Jain knew that if he waited too long to expand geographically, Carrum might lose its first-mover advantage in several markets. With limited resources, Jain needed to decide how to scale his young company: should Carrum enter the Chicago and Columbus markets with a guaranteed initial client base and then focus on selling the existing five bundles to new customers there; or, should the company add new bundles to its product line through the existing provider networks in the three markets it currently served?