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This note describes sampling and t-tests, two fundamental statistical concepts.

The first two cases in this series are set in the financial services industry, and explore whether it is better for back-office workers to be generalists who provide the flexibility of being able to handle the complete range of transactions that the company faces or specialists who focus on a subset of the overall transaction mix. The objective is to introduce the advantages of demand pooling in reducing the variability associated with the forecasting of highly variable workloads, while also demonstrating the benefits to worker learning and efficiency improvements that can come from specialization. The case is set at the Retail Investor Group Operations of the Vanguard Group, the mutual funds and ETF giant. Karin Risi, the managing director, is faced with a back-office operation that hasn't kept up with massive transaction growth, one that is struggling under the weight of mounting client phone call and transaction volumes, client complaints, and buckling employee morale. And worse, the press was taking notice. The (A) case details the complexity in the growing backlog and frames the question of whether they should pursue a specialist model. The (B) case, for distribution in class, details the impact of an initial segmentation of workload into eight categories and poses additional questions for class discussion and analysis.

The first two cases in this series are set in the financial services industry, and explore whether it is better for back-office workers to be generalists who provide the flexibility of being able to handle the complete range of transactions that the company faces or specialists who focus on a subset of the overall transaction mix. The objective is to introduce the advantages of demand pooling in reducing the variability associated with the forecasting of highly variable workloads, while also demonstrating the benefits to worker learning and efficiency improvements that can come from specialization. The case is set at the Retail Investor Group Operations of the Vanguard Group, the mutual funds and ETF giant. Karin Risi, the managing director, is faced with a back-office operation that hasn't kept up with massive transaction growth, one that is struggling under the weight of mounting client phone call and transaction volumes, client complaints, and buckling employee morale. And worse, the press was taking notice. The (A) case details the complexity in the growing backlog and frames the question of whether they should pursue a specialist model. The (B) case, for distribution in class, details the impact of an initial segmentation of workload into eight categories and poses additional questions for class discussion and analysis.

How should ZEISS, the German manufacturer of precision optical and optoelectronic systems manage two historic businesses that operated fairly autonomously? The Industrial Quality Solutions (IQS) business sold measurement equipment to manufacturing companies in sectors like automotive and aerospace. The Research Microscopy Solutions (RMS) business sold into scientific research laboratories and industrial materials laboratories. The two units had many similar characteristics. Both served demanding customers in complex and competitive market segments, and the use of RMS microscopy products in materials research meant an increasing amount of cross-selling into IQS customers. Yet there were many differences in the sales processes, product development processes, and approaches to product and market planning. RMS and IQS had very different ways of working, and most team members would say that the organizational cultures and the customers were very different as well.

This case describes the efforts of the Bill & Melinda Gates Foundation to lower the cost of production of vaccines to prevent polio infections. It is an abridged version of Case No. 620-021 with less emphasis on comparison between traditional and the new compact modular process developed with the Foundation's funding. It focuses more on the lowering of entry barriers to vaccine manufacture and some of the perceived risks associated with that.

This case examines four Special Economic Zones in Myanmar. While the country's development had been hobbled by a complex history of military rule, ethnic conflict, and international sanctions, as it pursued liberalization it sought avenues to developing its economy. The four zones described in the case - Dawei, Kyaukphyu, Thilawa, and the New Yangon City project all had different roots and different motivations. The different rates of progress of each reflected the interests and approaches of each of the projects' participants.

Vaccines for children has been a long-standing focus for the Bill & Melinda Gates Foundation, and their critical role in public health made their production an important economic and political issue. This case describes the Foundation's investment in a breakthrough vaccine manufacturing platform for the Sabin inactivated polio virus. While the new technology promised a much lower cost per dose, it also raised questions about the consequences of lowering entry barriers to vaccine production, as maintaining high quality and production standards, a strong regulatory environment were critical to protecting the integrity of the vaccine supply. The new technology also threatened to encourage more developed country vaccine manufacturers to exit the market, not an outcome the Foundation was hoping for, as they possessed the capabilities and resources to invest in future developments. It raises the question of whether vaccines are a public good, and who should be responsible for their production.

This case examines the competition between ports and port operators in the Pearl River Delta over the last four decades. The cities surrounding the Pearl River estuary are the "workshop of the world," and the development of manufacturing in the region was heavily dependent on efficient container shipping. As China has opened up and drawn more direct trade traffic to Shenzhen and Guangzhou ports, the operators in Hong Kong have had to adapt. More change is afoot, and Hong Kong may have to reinvent itself again.

This case describes the evolution of Kazakhstan's rail connectivity strategy post-collapse of the Soviet Union and its now central role in China's Belt and Road Initiative. This meant shifting from a north-south orientation towards east-west, as well as the development of new border-crossing facilities, special economic zones, and a new middle route that crossed the Caspian Sea. Unlike many other BRI initiatives that involved loans from China, Kazakhstan funded the modernization and upgrade by itself. Now the question was how soon demand would grow to fill the waiting capacity, as other bottlenecks on the Trans-Eurasian land route connecting China with Europe were beyond the country's control.

Zhejiang Geely Holding Company's acquisition of Volvo cars was widely viewed with skepticism because of the poor track record of cross-border auto industry acquisitons. This case looks at the acquisition and post-acquisition integration from the point of view of Chinese managers at Geely. A companion case, 613-042 Volvo Cars: Acquisition by Geely looks at the acquisition from the point of view of Swedish managers at Volvo.

Mitch Lowe, the CEO of MoviePass, was having trouble convincing people of the viability of the company's business model. The company was building a multi-sided platform, and was planning to extract value from increasing traffic to movie theaters through a number of mechanisms. It also appeared to making assumptions around its flat-rate pricing model. By making some assumptions, this case affords an opportunity for students to practice with discovery-driven planning.

Zheijiang Geely Holing Company's acquisition of Volvo Cars was widely viewed with skepticism because of the poor track record of cross-border auto industry acquisitions. This case looks at the acquisition and post-acquisition integration from the point of view of Sweedish managers at Volvo. A companion case, 613-041 Zheijiang Geely Holding Group: Acquisition of Volvo Cars looks at the acquisition from the point of view of Chinese managers at Geely.

Komatsu's Komtrax system started as a way of remotely monitoring and tracking equipment for the purpose of improving operational efficiency. This case follows its evolution towards other uses including demand forecasting for its sales, marketing, and production operations.

This note on supply chain management provides background for the seven class supply chain module in the Technology & Operations Management required curriculum course taught at the Harvard Business School. This module includes four broad topics: sourcing and supply chain structure, supply chain coordination, coping with uncertain demand, and supply chain visibility.

Kaizen, meaning change for the better in Japanese, is a set of activities directed at improving standardized work, equipment, and procedures for carrying out daily production or other business operations. It was popularized by Toyota as an integral part of its Toyota Production System. This note provides describes some of the underlying practices, and a simple outline for conducting a kaizen event.

It used to be an article of faith that technology-intensive product manufacturers, automakers, or white goods makers could capitalize on their long-standing engineering and design leadership to cement their position worldwide. But that's no longer the case. Today, young upstarts in many product segments, especially from China, can develop world-class design and production capabilities in short periods of time. "In some cases, they are closing gaps with long-established incumbents and becoming market leaders within a decade,"writes Harvard Business School professor Willy Shih. Three main factors drive this: (1) blatant copying of intellectual property, (2) governments pressuring companies to share technology in exchange for rights to do business, and (3) normal knowledge spillover as workers move from multinationals to local companies. But other forces, the author argues, are accelerating commoditization and making product differentiation increasingly difficult to sustain.Knowledge, particularly the tacit know-how that takes years to develop, now flows through pathways that we take for granted. It is embedded in the tools used to design and manufacture products, or it is incor-porated into the building blocks that are used to build more-complex systems. Young competitors, armed with this knowledge, can now skip years of practice and become competitive threats almost instantly.The amount of commoditization pressure a company faces, the author writes, depends on the number of complementary assets it needs to operate successfully and how difficult they are to replicate. Such assets could be other tools or specific operating capabilities. If a producer needs to use a tool in conjunction with other tools or recipes, it's easier to protect the product space. However, if the tool is the keystone and complementary assets are easy to acquire, commoditization is the likely outcome.

This case describes Ekol, an intermodal transportation and logistics company, and how it manages capacity planning. Its busiest routes linked motor vehicle assemblers in Germany and Turkey with many of their parts suppliers, but it had also developed key links in fast-fashion supply chains. It used combinations of land, short-sea, and rail routes to provide different levels of service. The challenge was maximizing utilization of its trucks and trailers, especially on key bottleneck links, in the face of unbalanced traffic. To address the issue Ekol developed a consolidation center in Turkey and a cross-dock deconsolidation center in Germany, its largest market. As Chairman Ahmet Musul and his team looked at ways to squeeze out more capacity, they reconsidered their planning model and whether they should build more consolidation/deconsolidation centers to optimize costs and wring out more efficiency in its operations.

Spreadsheet supplement for case 618712.

BeiGene was a biopharmaceutical company founded on exploiting a temporal regulatory policy discontinuity. Because of regulatory challenges in China, most innovative new drugs launched there four to six years after their initial U.S. launches. This gave BeiGene a window of opportunity to develop drug candidates toward known targets with known mechanisms of actions that would allow it to become first-in-class in China. But how well would the company's strategy hold up to the 2017 regulatory reforms?

This note describes four broad categories of process architectures and then examines the nature of task assignment that typically would be found in a factory organized along the lines of each process type. It then delves more deeply into work flow policies, materials handling, and line pacing for the assembly line, since this process architecture is so widely used for the mass production of everything from smartphones to automobiles.