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In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious financial position, with funds to continue operating for about 18 months, the company was considering how it could raise more money. Possibilities included finding a buyer, convincing an entity to take them private with a cash infusion, securing a private investment in public equity (PIPE) deal, and trying to interest institutional investors to buy shares. Second, given the positive results just reported and the pending outcome of ongoing trials, management began assessing the commercial potential for its treatment for lung infections in CF patients. The executives had to define the likely total addressable market (TAM) as well as what could be a reasonable price to charge; other go to market challenges, such as educating the medical community and convincing payers to cover the treatment, would also need to be overcome. Lastly, if the ongoing trials in CF patients also produced positive results and additional funding was secured, the company had to decide on future R&D efforts. Options ranged from developing and testing phage cocktails to treat low-risk/low-reward conditions (such as prosthetic joint infections or PJI), medium-risk/medium-reward conditions (such as infections associated with atopic dermatitis), or high-risk/high-reward conditions (such as inflammatory bowel disease or IBD).

Fibroheal Woundcare Pvt. Ltd. (Fibroheal) was the first company in India in the medical device sector to utilize the biomedical properties of silk. Launched in 2017, it focused on providing effective wound care to patients in a cost-effective manner. Fibroheal’s unique value proposition lay in its sustainable approach, ensuring balance across social, economic, and environmental dimensions. Results showed that Fibrocare's products could reduce wound-healing time by almost half. By the end of 2021, Fibroheal had about 15 products in its kit covering acute, chronic, and post-operative wounds. It had also engaged more than 1,000 farmers, as well as over 150 hospitals in more than 20 states across the country, and was affecting over 50,000 patients. However, there were challenges around building trust among stakeholders in the medical device market, where big multinational firms were already operating. Considering the challenges, how could Fibroheal expand in the medical device market under its founder’s strategic leadership? How could the company build on the existing positive customer responses? What should be the firm’s expansion strategy?

Bowtie Life Insurance Company Limited (Bowtie) was the first virtual insurance company licensed by the Hong Kong Insurance Authority. Since obtaining the licence in 2018 and raising two successful rounds of venture capital, Bowtie had developed into a reasonable size, of about a hundred employees, by early 2022. Bowtie was focused on developing and selling medical insurance products under the Voluntary Health Insurance Scheme (VHIS), while also selling term life insurance. The founders’ intention is to bring cheaper, more user-friendly insurance products directly to the mass market through online channels, while disrupting the traditional insurance industry by eliminating agents and brokers. The COVID-19 pandemic in 2020–2022 brought both opportunities and risks to the virtual insurance sector. While online purchases increased significantly during this period, the overall gloomy macroeconomic outlook put downward pressure on insurtech, fintech industries, and the venture capital that funded them. With Hong Kong’s mortality rates soaring, Bowtie had to consider the effects of the pandemic on its profitability and determine its future strategy. While continuing to focus on the VHIS segment, how should Bowtie expand into other product segments? When and how should the company expand to Mainland China and/or other neighbouring markets outside of Hong Kong?

Spreadsheet to accompany product W32456.

Fibroheal Woundcare Pvt. Ltd. (Fibroheal) was the first company in India in the medical device sector to utilize the biomedical properties of silk. Launched in 2017, it focused on providing effective wound care to patients in a cost-effective manner. Fibroheal's unique value proposition lay in its sustainable approach, ensuring balance across social, economic, and environmental dimensions. Results showed that Fibrocare's products could reduce wound-healing time by almost half. By the end of 2021, Fibroheal had about 15 products in its kit covering acute, chronic, and post-operative wounds. It had also engaged more than 1,000 farmers, as well as over 150 hospitals in more than 20 states across the country, and was affecting over 50,000 patients. However, there were challenges around building trust among stakeholders in the medical device market, where big multinational firms were already operating. Considering the challenges, how could Fibroheal expand in the medical device market under its founder's strategic leadership? How could the company build on the existing positive customer responses? What should be the firm's expansion strategy?

Bowtie Life Insurance Company Limited (Bowtie) was the first virtual insurance company licensed by the Hong Kong Insurance Authority. Since obtaining the licence in 2018 and raising two successful rounds of venture capital, Bowtie had developed into a reasonable size, of about a hundred employees, by early 2022. Bowtie was focused on developing and selling medical insurance products under the Voluntary Health Insurance Scheme (VHIS), while also selling term life insurance. The founders' intention is to bring cheaper, more user-friendly insurance products directly to the mass market through online channels, while disrupting the traditional insurance industry by eliminating agents and brokers. The COVID-19 pandemic in 2020-2022 brought both opportunities and risks to the virtual insurance sector. While online purchases increased significantly during this period, the overall gloomy macroeconomic outlook put downward pressure on insurtech, fintech industries, and the venture capital that funded them. With Hong Kong's mortality rates soaring, Bowtie had to consider the effects of the pandemic on its profitability and determine its future strategy. While continuing to focus on the VHIS segment, how should Bowtie expand into other product segments? When and how should the company expand to Mainland China and/or other neighbouring markets outside of Hong Kong?

Spreadsheet Supplement for CaseW32456

Teresa Ward, founder of Grandma Treesaw’s Bannock (GTB), had recently received positive media coverage from the Canadian Broadcasting Corporation and was hoping to leverage it to grow her Yukon-based bannock-mix business. She was considering two options: expand her direct to consumer offer by working with Shopify Inc. to improve GTB’s e-commerce sales or grow her product portfolio by introducing two new flavours of bannock mix. A few questions loomed in Teresa’s mind: Could she do both? Did GTB have the organizational resources to pursue this expansion plan successfully? What should her implementation timeline look like? What financial analysis would need to be done to support the decision-making process? She wanted to decide which option to pursue in the next three to four weeks.

Teresa Ward, founder of Grandma Treesaw's Bannock (GTB), had recently received positive media coverage from the Canadian Broadcasting Corporation and was hoping to leverage it to grow her Yukon-based bannock-mix business. She was considering two options: expand her direct to consumer offer by working with Shopify Inc. to improve GTB's e-commerce sales or grow her product portfolio by introducing two new flavours of bannock mix. A few questions loomed in Teresa's mind: Could she do both? Did GTB have the organizational resources to pursue this expansion plan successfully? What should her implementation timeline look like? What financial analysis would need to be done to support the decision-making process? She wanted to decide which option to pursue in the next three to four weeks.

Laura Chavez was delighted beyond words when the Atelier Asymmetric Bow suite, designed by her luxury jewellery company Lark & Berry, won the 2019 Goldsmiths' Craft and Design Council Graff jewellery award. The Graff Award was the jewellery industry's equivalent of the Oscars award for Best Picture and conferred immense prestige on its maker. Unfortunately, the euphoria of the win lasted barely 24 hours for Laura. The award had made history: it was the first time that a piece made exclusively with lab-grown diamonds had scooped the top Craft and Design Council prize. But, when the awards committee realised the suite had been made with lab diamonds, they insisted that Lark & Berry disassociate themselves from the prize - even though they had designed and commissioned the piece

Paytm was an Indian financial technology company. Since its launch in 2010, it had built a dominant payments system in India, comprising mobile wallets, offline payments via QR codes, and a payments bank that offered no-frills banking. However, in 2016, the Indian government launched a free, publicly available digital payments platform, the Unified Payments Interface (UPI), that removed barriers for entry into the payments market. With its dominant advantage eroded, Paytm had to strategize a new business model to ensure profitability. By 2023, the company's leadership was confident that Paytm had found a profitable model and was on the right path. But they were still debating what was next for the company. Which business vertical should it focus on? Should it expand internationally? Which path would help Paytm become India's dominant fintech company?

In February 2023, Emtech's founder Carmelle Cadet is facing a dilemma. Rapidly running out of cash, Cadet has a term sheet from a leading VC but has a choice of how to structure the investment. The decision will have significant implications for Cadet's own stake, as well as her ability to attract top talent. One factor influencing Cadet's decision is her vision of creating a digital currency platform that will facilitate financial inclusion and other values throughout the world. Founded in 2018, Emtech first offered central bank digital currencies to world governments, digital fiat currencies that could be a tool for emerging economies to offer benefits and administer social programs more efficiently. The company later began developing regulatory sandboxes, which allow governments and fintechs to experiment to optimize regulatory environments, while working with financial service providers on innovation and regulation of new products.

This case details the 2020 launch and subsequent scaling of UST's Open Talent initiative, a program to integrate freelancers from digital platforms into its workforce. The case highlights how the shifting post-pandemic world, including layoffs, wage inflation, and return to office policies interact with the momentum of organizational change. Readers are left to grapple with how UST's leaders should take the program forward.

In early October 2022, the ASX-listed mineral exploration company Sheffield Resources announced its final investment decision to proceed with the Thunderbird mineral sands project, its only project under development. Olivia Montalbano’s investment banking firm had decided to provide coverage of Sheffield’s stock and asked her to determine a fair value estimate. The investor’s bankable feasibility study (BFS) provided an estimate of $1.84 per share, but the stock price was only $0.47. What troubled Montalbano was that the BFS employed a real discount rate of 8%, which seemed low, given typical mining project risk. Montalbano’s immediate task was to develop her own estimate of the project’s cost of capital.

Fundrr was a South Africa-based alternative funding business that launched in 2018. The business’s goal had been to disrupt the South African business lending landscape, specifically at the small- to medium-sized enterprise (SME) level where the majority (about 71 per cent) of SMEs generated annual revenues of less than R200,000 and employed between two and five people. Reflecting on the company’s journey in October 2021, the company’s founders realized that Fundrr had weathered the COVID-19 storm and had grown 630 per cent between September 2020 and September 30, 2021. However, there was a discrepancy between their current client base and the founders’ vision for the company as a disruptive, innovative, entrepreneurship-friendly alternative funder seeking to offer financial backing options independent of those granted by traditional banking institutions. The typical Fundrr client was usually in their fifties and male. Operating on a continent with the youngest population in the world, what did this say about their marketing and brand positioning? How could they apply the same resourcefulness and relevance to position the business into the future?

Given the turmoil in the cryptocurrency sector, some say the blockchain revolution is over. Others think market setbacks and implementation challenges will eventually be overcome, potentially enabling the mass adoption of a decentralized “Web3” that will revolutionize how people work, play, and earn a living. So, what should executives think? In this Ivey Business Journal interview, Alex Tapscott discusses what has happened since the publishing of Blockchain Revolution, along with his new book Web3: Charting the Internet’s Next Economic Frontier. Tapscott explains how with the rise of Web2, Internet users agreed to a system of digital feudalism by giving away their data in exchange for free services. The future he sees will invert the model from digital feudalism to a form of self-sovereign identity where you control and own your data, and you decide how and when it’s used—and if it’s used, you can get compensated. People will enjoy more privacy rights and many might end up working for a decentralized autonomous organization (DAO), which will benefit people in places where local markets don’t offer many employment opportunities. Creators will enjoy new ways to connect with fans and directly earn money from them, while fans will have a new way to experience the creativity they enjoy. However, without decentralized blockchain we’ll end up with hyped-up databases controlled by a single company, which wouldn’t be Web3 but “virtual Disneylands.”

Suparshva Swabs India (SSI), a family-owned firm started by Brij Mohan Jain and his sons in 1992, when India was going through liberalization, began its journey in the personal-hygiene category by launching high-quality cotton swabs (also known as cotton buds). SSI had steadfastly managed environmental challenges on the regulatory, economic, financial, and competitive fronts to offer good-quality products in India at an affordable price. In early 2020, as COVID-19 struck the whole world and the Government of India was under pressure to increase the number of COVID-19 tests conducted per day, the high costs of importing cotton swabs from the United States, Italy, and China exacerbated the crisis, making real-time polymerase chain reaction (RT-PCR) tests unaffordable for the average Indian and reducing the number of tests conducted per day. SSI identified the opportunity to produce swabs indigenously in India and substantially bring down the costs. With very little time to respond to the challenge and meet the government's demand with a price acceptable to all stakeholders, SSI worked within severe time and cost constraints to make this possible. In August 2022, as the intensity of COVID-19 tapered off and a slew of substitute consumer-friendly methods for testing were arriving in the pipeline, SSI needed to determine what strategic alternatives were available for growth from this point.

Already a leader in the edtech space since its 2008 launch, Khan Academy was now one of the first edtech organizations to embrace generative artificial intelligence ("genAI"). In March 2023, Khan Academy began beta testing Khanmigo, a genAI "guide" and tutor built with ChatGPT, a technology developed by the San Francisco-based AI research lab OpenAI. In addition to simulating historical and fictional characters, Khanmigo assisted students with learning math, debugging code, writing, and completing other learning exercises. Khanmigo was also designed to help teachers develop lesson plans and quizzes, brainstorm creative teaching approaches, and evaluate students' progress, among other tasks. As the Founder and CEO of Khan Academy, Sal Khan felt that Khanmigo might just be "that holy grail we've all been reading about in science fiction for years, about an artificial intelligence that could emulate a human tutor." However, he pondered what the societal-and, for Khan Academy, organizational-risks might be of using OpenAI's ChatGPT. Was it possible that Khanmigo would introduce new problems or exacerbate existing problems in classrooms around the world? If so, what more could Khan Academy do to prevent such outcomes? How might Khan Academy itself need to evolve to support and shepherd this new tool? At the most extreme, might genAI increase Khan Academy's impact manifold, or might the new technology diminish its impact?

After importing three hundred bags of ground sacha inchi, a seed with promising nutritional benefits, from Peru, Kayla Gray has important decisions to make. Her new venture, Sachi Superfoods, is ready to launch; however, she does not have a clear plan on how to best market her product. Gray must decide on the best market segment to pursue in addition to the most effective marketing channel for her product.