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In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in the lab. The company hoped to create 500,000 tons of products by 2030, and by 2023, had produced proof of concepts of cotton, coffee, and cacao. Bueno had a number of decisions to make. How should the company scale? Where should it locate production? Should it build its own production facilities, or license its intellectual property to partner firms? Should the company continue operating an office in Brazil, or centralize operations in Boston? The answers to these questions would point the way forward, but which path was best?

Entrepreneurs often struggle with the question of whether to found solo or alongside one or more cofounders. This case is comprised of three vignettes detailing common founding scenarios: the first-time technical founder; the serial commercial founder; and the MBA co-founders who are friends first. Coupled with robust research, this case offers students the opportunity to break down the roles, responsibilities, relationships, and resources of a founding team and determine when and why they should found alone or seek a cofounder.

As a gaming company that was neither energy nor emissions-intensive, 37 Interactive Entertainment developed a range of measures to reduce its carbon emissions over several years. These included establishing an industry-leading method for calculating the company's carbon footprint, committing to become carbon neutral, purchasing renewable energy, and developing games with environmental themes. Company executives, including cofounder and Vice Chairman, Zeng Kaitian, were committed to finding more ways to ensure the company lived up to its environmental responsibilities, especially by leveraging its advantages as a gaming company to influence society. Zeng also held discussions with the board's Sustainable Development Working Group on integrating social responsibilities into the company's strategy and day-to-day operations.

In 2019, TetraScience CEO "Spin" Wang needed advice. Five years earlier, he had cofounded a startup that saw early success with a hardware product designed to help laboratory scientists in the biotechnology and pharmaceutical spaces more easily collect data from various instruments. At the time, longtime technology CEO Patrick Grady warned the cofounders that the growth was illusory, and that they should think about how to better structure their business and to start anew thinking about design in four facets-category, product, organization, and ecosystem. Paying attention to these "first principles," Grady believed, would lead TetraScience to pivot away from its initial hardware business and into a new cloud-based service. The cofounders had rejected Grady's advice at first, but in 2019, with the company facing bankruptcy, Wang called him up again to talk strategy.

<p align="justify">The Beijing Stars and Rain Education Institute for Autism (Stars and Rain) was established in 1993 as the first private non-profit organization to provide educational services for children with autism in China. As a social enterprise, Stars and Rain worked to connect with various partners, raise funds through multiple channels, and co-operate with social welfare organizations. In addition to providing better autism rehabilitation services, it was also dedicated to facilitating family intervention and pre-employment training for adolescents with autism through its professional service and social influence. Since 2020, the spread of the COVID-19 pandemic had led to a continued downturn in the global economy, which greatly affected Stars and Rain’s operations and funding. How could the organization obtain a more stable source of funding, achieve sustained viability, and execute on its mission, vision, and strategic priorities?

The Beijing Stars and Rain Education Institute for Autism (Stars and Rain) was established in 1993 as the first private non-profit organization to provide educational services for children with autism in China. As a social enterprise, Stars and Rain worked to connect with various partners, raise funds through multiple channels, and co-operate with social welfare organizations. In addition to providing better autism rehabilitation services, it was also dedicated to facilitating family intervention and pre-employment training for adolescents with autism through its professional service and social influence. Since 2020, the spread of the COVID-19 pandemic had led to a continued downturn in the global economy, which greatly affected Stars and Rain's operations and funding. How could the organization obtain a more stable source of funding, achieve sustained viability, and execute on its mission, vision, and strategic priorities?

<p align="justify">The case describes how Zhuiyi, a leading conversational artificial intelligence (AI) start-up in China, developed its growth strategy and made transitions in the face of product commercialization challenges. The crux lies in the low customer satisfaction rate of AI products, which could be endogenously attributed to mismatched expectations among customers and the founding team in the product development process as well as to the lack of vertical industry knowledge among executives and employees. Zhuiyi needs to make a strategic choice between: a) developing new AI products by making large and risky research-and-development investments or b) devoting more resources to product customization and expanding the market through client diversification.

In 2013, Aoibheann O'Brien and Iseult Ward founded FoodCloud, a non-profit social enterprise that aimed to address food waste and food insecurity issues. Through its technology platform, Foodiverse, FoodCloud connected surplus food from retailers with community groups in need. By 2022, the company had partnered with Tesco Ireland and Tesco UK, and was rolling out its solution in the Czech Republic and Slovakia. O'Brian and Ward were eager to scale their solution globally, but funding the growth of a non-profit posed a challenge. Options included spinning off Foodiverse into an investment-seeking entity or retaining non-profit status to raise a social impact bond. The founders also sought to amplify their impact in Ireland to position the country as a leader in food waste reduction. The co-founders wondered whether to focus on developing an exemplary local sustainable food system or expand their proven technology solution globally, and where to find the funds for their chosen path.

The case describes how Zhuiyi, a leading conversational artificial intelligence (AI) start-up in China, developed its growth strategy and made transitions in the face of product commercialization challenges. The crux lies in the low customer satisfaction rate of AI products, which could be endogenously attributed to mismatched expectations among customers and the founding team in the product development process as well as to the lack of vertical industry knowledge among executives and employees. Zhuiyi needs to make a strategic choice between: a) developing new AI products by making large and risky research-and-development investments or b) devoting more resources to product customization and expanding the market through client diversification.

Research shows that innovators have a poor track record of predicting which of their own ideas will result in breakthroughs. But some ideas that appear to be incremental at first eventually prove to be blockbusters. Carrying more ideas through to incubation gives both the company and the broader market a chance to learn more about them and for unanticipated use cases to emerge.

Lego Group's crowdsourced innovation strategies have long been a model for open innovation. New research into how the company has advanced its practice of integrating customer communities into its idea-generation process yields additional lessons in how to integrate customer input into product development, and how to nurture creative customer communities.

Alex Tapscott, business author and alternative investment market professional, explains why he thinks believing in a decentralized future is as deadly practical as Blaise Pascal's wager on God.

Fundrr was a South Africa-based alternative funding business that launched in 2018. The business's goal had been to disrupt the South African business lending landscape, specifically at the small- to medium-sized enterprise (SME) level where the majority (about 71 per cent) of SMEs generated annual revenues of less than R200,000 and employed between two and five people. Reflecting on the company's journey in October 2021, the company's founders realized that Fundrr had weathered the COVID-19 storm and had grown 630 per cent between September 2020 and September 30, 2021. However, there was a discrepancy between their current client base and the founders' vision for the company as a disruptive, innovative, entrepreneurship-friendly alternative funder seeking to offer financial backing options independent of those granted by traditional banking institutions. The typical Fundrr client was usually in their fifties and male. Operating on a continent with the youngest population in the world, what did this say about their marketing and brand positioning? How could they apply the same resourcefulness and relevance to position the business into the future?

Abraham Heifets and his co-founder, Izhar Wallach, had founded Atomwise to develop i) an AI engine to transform drug discovery by creating better medicines faster, and ii) a machine learning-based discovery engine that combined the power of convolutional neural networks with massive chemical libraries to discover new small molecule medicines. Computational chemists employed at big pharmaceutical companies were interested in trying these engines and associated tools on their projects. On the other hand, Atomwise could keep its tools for itself if it were to become a pharmaceutical company on its own. These options would chart very different courses for Atomwise. The case articulates the dilemma facing Heifets and Wallach, as they contemplated committing to a business model that would leverage the strengths of the technology to deliver value for patients and for investors.

In March 2020, the German online travel experience platform GetYourGuide faced an abrupt drop in revenues in the wake of the COVID-19 pandemic. Prior to the drop, the company had been thriving, grown from a simple idea thought up by a group of friends in a student dormitory into a market-leading company in the travel experience industry with a valuation of over US$1 billion (a "unicorn" start-up) and more than 600 employees across fifteen global offices. Co-founder Johannes Reck and his team needed to determine a path forward-but how to prioritize responses to the crisis? What would the impact of any responses be on the company's longer-term strategy? And how could the responses be aligned with the company's values, which centred on entrepreneurial vision and commitment to employees? Whichever action plan was chosen, decisions would have to be made swiftly.

Opened in January 2021, the medical centre of the Chinese University of Hong Kong (CUHK), CUHK Medical Centre (CUMC), was a non-profit teaching hospital wholly owned by the university. In December 2022, Professor Hong Fung, the executive director and chief executive officer, knew that the CUMC board of directors would soon be asking how he was going to ensure that the privately operated CUMC would remain financially sustainable while still achieving its mission and vision-offering quality healthcare services at affordable and transparent package prices-and returning all surpluses from healthcare services to the hospital to support its future development and the CUHK Faculty of Medicine's research and teaching.

Founded by a formerly incarcerated job seeker, Honest Jobs' mission is to be the hub where people with criminal records come to build careers and employers come to find great talent. Honest Jobs faced early challenges as a two-sided platform for justice-involved job seekers and employers, but by 2022, the organization had partnered with 1,200+ employers and supported 40,000+ job seekers who were reintegrating with society. As 2023 approached, founder and CEO Harley Blakeman looked to raise a Series A round to supplement the $3M+ that had been raised in prior rounds. The decision Blakeman faced was whether to pursue impact-oriented VC firms or traditional firms and how much money to raise given hiring needs and expansion plans.

In 2023, executives with ReMo Energy (founded 2020) were deciding which size ammonia plant to build as their first project. Their innovative model produced ammonia - useful for making fertilizer and for energy storage - from renewable energy, and they had received funding from a prominent environmentally-conscious venture capital fund. However, they needed more funding to build their first plant. Smaller plants were less efficient, but bigger plants were riskier, and different potential funders had different priorities. The case prevents three size options for ReMo's first plant, with a detailed model of how various present and future factors - the price of ammonia, power supply, taxes, and more - affect risk and return.

In 2020, the tuition and coaching industry in India was severely hit due the COVID-19 pandemic and subsequent nationwide lockdowns. With physical classes suspended, many private tutors and coaching institutes closed their businesses. Teachers and educators found limited options for conducting classes online, and it was challenging to manage and monitor teaching-related activities. Founded in May 2020, Teachmint, the Bengaluru-based education technology (edtech) start-up, provided a one-stop edtech infrastructure solution for teachers, educators, and institutes. With a focused business-to-business model, Teachmint grew leaps and bounds in its first year of operations. The company had begun international expansions by partnering with edtech companies in Southeast Asia and the Middle East. However, Teachmint's chief executive officer was debating whether it was the right time to go global or whether his company should focus on the Indian edtech market, which was competitive and featured several large players.

Sunil Koshy considered himself a "passionpreneur;" after quitting a well-paid job as a software engineer, he chased his passion for singing and founded From Mug to Mike (FMTM), a start-up that helped amateur singers polish their singing skills. Stemming from Koshy's passion, FMTM had evolved into a business venture with viable products, services, and a scalable business model. To scale up FMTM, Koshy needed to decide whether the business should take a geography- or a product-led route.