By 2016 the explosion of digital advertising was a global phenomenon. And many industry observers believed that programmatic advertising, that is digital advertising allocated through automated marketing systems, was the future of digital advertising. In a programmatic advertising environment, buyers and sellers of online (digital) advertising connected over an exchange buying and selling available inventory. For advertisers, programmatic marketing offered the promise of less costly and more targeted and effective placements. This Primer discusses the programmatic advertising eco-system and the challenges inherent in negotiating this system (e.g., the persistence of ad blocking and the threat of fraud)-as well as future growth opportunities for programmatic advertising.

James Reid, the newly appointed GM of Troubled Spain, has been given a mandate by the CEO of Troubled Inc. to turn the subsidiary around within six months. Troubled Spain has experienced several years of poor performance that cannot be explained by either sluggish demand or lagging technology. The case provides information about interviews that James had with several employees, describing the role of the employee and giving insights into the issues that they see the company facing. These interviews are complemented by three charts prepared by consultants that James hired to conduct an internal audit of collaboration, communication and informal leadership in the organization. James needs to transform the organization within six months; however, this implies changing relationships that have been developed over decades and clarifying roles and boundaries that have been blurred over many years. The case challenges students to take James' position and identify the issues of Troubled Spain to develop an action plan in order to address the challenges facing the company. James needs to address: 1) issues concerning Troubled Spain's formal structure, 2) issues regarding its informal structure, including leadership issues, and 3) issues stemming from the combination of both formal and informal features. Case B provides information about what happened next and may be distributed at the end of the session.

James Reid, the newly appointed GM of Troubled Spain, has been given a mandate by the CEO of Troubled Inc. to turn the subsidiary around within six months. Troubled Spain has experienced several years of poor performance that cannot be explained by either sluggish demand or lagging technology. The case provides information about interviews that James had with several employees, describing the role of the employee and giving insights into the issues that they see the company facing. These interviews are complemented by three charts prepared by consultants that James hired to conduct an internal audit of collaboration, communication and informal leadership in the organization. James needs to transform the organization within six months; however, this implies changing relationships that have been developed over decades and clarifying roles and boundaries that have been blurred over many years. The case challenges students to take James' position and identify the issues of Troubled Spain to develop an action plan in order to address the challenges facing the company. James needs to address: 1) issues concerning Troubled Spain's formal structure, 2) issues regarding its informal structure, including leadership issues, and 3) issues stemming from the combination of both formal and informal features. Case B provides information about what happened next and may be distributed at the end of the session.

This case examines the strategic choices and evolving business model of Imprimis Pharmaceuticals from the perspective of CEO Mark Baum. The A case provides a brief history of the company and of the compounding business, outlining the challenges faced by Imprimis in 2013. At the time, Imprimis was in the process of seeking FDA approval for a branded drug called Impracor. This process, already difficult, was further complicated by recent manufacturing issues. Meanwhile, the opportunity arose for Imprimis to purchase a technology related to compounded ocular injections. Because of the different competencies and business models required for the traditional pharmaceutical business vs. pharmaceutical compounding, Imprimis did not have the resources to pursue both of these options at once. Instead, Baum had to decide whether or not to abandon the company's previous focus on Impracor and to delve headlong into the compounding business. The two paths would require vastly different approaches to marketing, R&D, and manufacturing, so that either decision would shape the future of the company for years to come.

This case is a supplement to Imprimis (Case A). It describes the company's decision to enter into the pharmaceutical compounding business in 2013-14. Imprimis purchased a compounded ophthalmological medication called Dropless Therapy, which was injected into patients' eyes post-cataract surgery, with the aim of replacing a complex regimen of prescription eye drops. After a successful launch of the compounded medication, Imprimis ran into complications when Medicare changed its policy regarding payment for the drug. Under the new policy, not only would Medicare not cover the medication, but patients could no longer pay for it out of pocket. Instead, the cost had to be absorbed by the physician or surgery center. Imprimis now had to figure out a way to deal with the effects of this policy, whether that be by lobbying for a policy change, creating a compounded eye drop treatment of their own, or moving out of the cataract treatment business entirely.

This case is a supplement to Imprimis (Case A) and Imprimis (Case B). Set in 2015, it first describes Imprimis's decision to introduce its own line of compounded eye drop medication called LessDrops. The case then examines the moral dilemma faced by CEO Mark Baum, who was struck by the problem of high drug prices in the United States. Recent, drastic price hikes on pharmaceutical drugs, such as those initiated by Turing Pharmaceuticals under CEO Martin Shkreli, had recently brought media attention to this issue. Baum believed it would be relatively easy for Imprimis to create compounded versions of many of the affected drugs, which could increase competition in the pharmaceutical industry and lessen the strain both on patients and the healthcare system as a whole. However, doing so would require the company to raise capital, strengthen its sales force, and increase its manufacturing capabilities. The decision was further complicated by the relatively low barrier to entry, and by the ubiquitous nature of the drug pricing problem. Baum had to decide whether Imprimis should stick with its already-successful ophthalmology business, or begin the endeavor of combatting high drug prices, going up against powerful competitors in the drug industry.

This case is a supplement to Imprimis (Case A), Imprimis (Case B), and Imprimis (Case C). It describes Imprimis's 2015 decision to develop a $1 per pill compounded alternative to Daraprim, the branded drug that had recently undergone an extreme price hike, raising its price to $750/pill. Imprimis also created compounded alternatives to several other branded drugs, and made investments to increase its manufacturing capabilities. The company now had to decide where to focus its efforts in the future. In developing innovative compounded formulations, should it base its decisions on market size, either by population or dollar size? Should it concentrate instead on the level of exploitation by the branded drug manufacturers--how much they had raised prices by, in what amount of time? Or should it decide instead based on the life-threatening nature of the disease, regardless of how many people were afflicted? The company had to balance these choices with the expansion of its core ophthalmology business while continuing to raise funds from investors.

Founded in 2013 as a laundry service featuring online ordering for home pickup and delivery, China's edaixi (eWash) illustrated the online-to-offline (O2O) business model. As yet unclear in 2016 was the optimal way to organize third-party laundry service providers, locally sourced teams of freelancers, and in-house operations.

Founded in 2013 as a laundry service featuring online ordering for home pickup and delivery, China's edaixi (eWash) illustrated the online-to-offline (O2O) business model. As yet unclear in 2016 was the optimal way to organize third-party laundry service providers, locally sourced teams of freelancers, and in-house operations.

In 2015, Ukraine needs IMF funding to bridge a projected $40 billion funding shortfall and is proposing a 40% "haircut" to Ukraine's $18 billion of Eurobonds. Can Ukraine negotiate a deal with its many creditors that will give it the funding the country needs on terms they can accept?

Raj Makam had spent months trying to restructure a 2006 investment he had made in National Truck Stops, Inc. (NTS) as a senior member of Oaktree Capital Management's (Oaktree) Mezzanine finance business within their Corporate Debt platform. It was the first time they had truly considered forcing a company into involuntary bankruptcy, which he clearly would prefer to avoid lest they risk losing their entire investment. As the company's financial position worsened, Oaktree's counterparties became increasingly difficult. It often seemed as if they were prioritizing their ongoing business relationships over the economics of their respective investments. Oaktree knew the cards were stacked in its favor legally, but did that really make a difference when the cost of perfecting its interests would be so expensive and difficult? Would this be a Pyrrhic victory?

Radically innovative thinker Sy Friedland was a decade or more ahead of the trends when he took the reins of Boston's venerable Jewish Children & Family Services in the late 1990s. A career clinical social worker, Friedland was also a visionary who knew that the future of building sustainable social services and nonprofits lay in the willingness of nonprofit workers to embrace "for-profit" concepts, attitudes and best practices. Friedland's total transformation of JF&CS enabled the agency to thrive and become self-supporting. When Friedland decided to step down after 17 years, he knew the agency could suffer in the transition and took elaborate steps to avoid crippling his agency's fundraising capacity and minimize disruption, even calling in a highest-level corporate HR consultancy firm to reduce risk and assist in on-boarding his hand-picked successor. However, because he was focused exclusively on minimizing disruption, Friedland made some crucial errors. His handling of his transition ended up causing an uproar in the board that resulted in changes in governance and policies going forward-proving that even visionaries can make mistakes.

One of the biggest logistics services providers in Colombia, Servientrega started out as a one-man courier operation on the streets of Bogota in 1982. Jesus Guerrero, an enterprising messenger boy, set up his own delivery service at the age of 18. After attracting more clients than he could handle, he persuaded his sister Luz Mary to join the company and invest her savings in exchange for half of the shares. Before long, Servientrega was growing so fast that they employed other siblings. Jesus gave one brother a 5% share in the business, expecting his sister to do the same. However, she held on to her 50% and used her majority shareholder position to take over, forcing her brother out of the CEO job. Jesus began acquiring new logistics operations that he consolidated into the Guerrero Group, which today has 39 subsidiaries (including Servientrega) and employs 28,500 people. The lawsuits that plagued the former partners and put their venture at risk ultimately prompted Jesus to launch a competitor to Servientrega, RedServi.

Sembcorp Industries, a Singapore conglomerate with assets of over S$22 billion, was undergoing a change in leadership. Tang Kin Fei retired as group president and CEO in April 2017 after 30 years with the company. Overseas operations accounted for 63% of their Utilities business' net profit, which formed the bulk of group earnings in 2016. Sembcorp's global power portfolio had doubled in the last five years. Rapidly developing economies, hungry for energy to fuel growth and urbanisation, were their key targets. There were growing concerns on the execution risks of developing a project pipeline in these markets and the environmental, social and governance (ESG) challenges involved. Sustaining their growth path might not simply be a matter of building on past success and replicating their business model overseas. How would they manage the inherent risks and complexities of the emerging markets, namely India, Bangladesh, Myanmar and China, albeit ripe with opportunities?

Delta Plastics of the South developed a new software product, Pipe Planner, which was complementary to its core product, Polytube, used by farmers to irrigate crops in the delta region of Missouri, Arkansas, Mississippi and Louisiana. Pipe Planner helped farmers by calculating, for any particular field, the size of pipe needed, how to punch holes in the pipe and how long to irrigate. Using the software could lower the farmer's cost of irrigating by up to 25 percent particularly through savings of fuel and time. It also conserved water, an important issue for delta farmers. The software was a significant improvement to PHAUCET, a similar but free government program already in limited use in the delta. Company leadership was sure that the product would have a strong market, but sales were discouraging with fewer than 200,000 acres (less than three percent of the market) under Pipe Planner management after three years of development efforts. Company leaders must decide if Delta Plastics should continue to invest money and resources in Pipe Planner, and if so, how to market and encourage use of the Pipe Planner program software by farmers. In this case the students can study the initial failure of diffusion of a market innovation and analyze the factors that led to that failure in a particular social context-farmers in the delta region. The case is suitable for use in a class on communication, or product innovation and marketing, for upper level undergraduates or graduate students. Students use the diffusion of innovation analysis to propose and evaluate options for Delta Plastics regarding next steps in the marketing and promotion of Pipe Planner within its core market.

In late October 2012 the board of directors of Spanish industrial conglomerate Inveravante (IV) were set to have a meeting to examine the situation regarding an investment IV had made in Venezuelan oil company Vetra, and to consider possible ways to divest said company. As managing director of Avantegenera, one of the business units of IV, Luis García was appointed to present realistic options for divesting Vetra to the board of directors of IV, offering a valuation of Vetra and recommendations for the future. He knew that the members of the board believed that it was time for a change and to finally make some profit from the investment in Vetra. Since the proposal to invest in Vetra had been made to the board by Mr. García some years earlier, he was very keen to bring the venture to a successful completion.

The CIO of Fintech, Inc. -a billing-and-payment processing service for the alcoholic beverages industry must choose a cloud services provider for a new application for Fintech's clients. The CIO sees this initiative as a useful first step to take before moving other resources and services into the cloud. His staff briefs him on three providers: Amazon, Google, and Microsoft. Each provider offers services which fit Fintech's requirements, yet with important differences. The Fintech case addresses the perspective of a company purchasing cloud computing services, as opposed to a vendor selling cloud computing services. It offers the added benefit of describing an important specialist intermediary in the highly regulated and complex US alcoholic beverages industry. The case has been tested in MIS and IT Management classes in undergraduate, MBA, MS-IT and DBA programs. It introduces cloud concepts (SaaS, IaaS, PaaS), and provides an opportunity for students to consider technical, economic, operational and strategic factors when making mission-critical IT decisions such as moving an important application to the cloud. Students can also consider how to mitigate risks associated with particular providers. The instructor can use it to introduce students to pilot testing and issues in vendor selection and ongoing management. After considering strengths and weaknesses of each provider and the provider selection process, the instructor can ask students to recommend a provider and/or other steps Kwo should take before making a final decision.

In the fall of 2016, with the January 2017 deadline to file bills fast approaching, State Senator Jason Lewis was contemplating the details of a sugary drink legislative proposal in the Commonwealth of Massachusetts. Senator Lewis had a particular interest in legislative efforts to contain healthcare costs and prevent chronic disease through prevention and wellness approaches. He was particularly concerned about the rising levels of sugary drink consumption and associated conditions of obesity, diabetes, and dental caries, considering such drinks "a uniquely toxic food." As an experienced legislator he knew he was facing a tough battle and wanted to take an approach that would give the bill the best chance of succeeding. Senator Lewis explained, "Massachusetts should be leading the legislative effort to reduce sugary drink consumption in the Northeast. Significant opposition from the beverage industry is expected, but we have a real chance of making progress at the local and state levels."

This is an MIT Sloan Management Review article. To succeed in the long run, businesses need to create and leverage some kind of sustainable competitive edge. Although the authors say that advantages can still come from sources such as lower cost, intellectual property, motivated employees, and strategic leaders, they argue that in the knowledge economy, strategic advantages will increasingly depend on a capacity to make superior judgments and choices. Intelligent enterprises today are being shaped by two distinct forces. The first is the growing power of computers and big data, which provide the foundation for operations research, forecasting models, and artificial intelligence. The second is our growing understanding of human judgment, reasoning, and choice. Decades of research has yielded deep insights into what humans do well or poorly. In this article, the authors examine how managers can combine human intelligence with technology-enabled insights to make smarter choices in the face of uncertainty and complexity and thus gain a cumulative advantage in business. They note five strategic capabilities that intelligent enterprises can use to develop an advantage over competitors: 1. Find the strategic edge. In assessing past organizational forecasts, home in on areas where improving subjective predictions can really move the needle. 2. Run prediction tournaments. Discover the best forecasting methods by encouraging competition, experimentation, and innovation among teams. 3. Model the experts in your midst. Identify the people internally who have demonstrated superior insights into key business areas, and leverage their wisdom using simple linear models. 4. Experiment with artificial intelligence. Use deep neural nets in limited task domains to outperform human experts. 5. Change the way the organization operates. Promote an exploratory culture that continually looks for better ways to combine the capabilities of humans and machines.

This is an MIT Sloan Management Review article. Across the world, people today are living longer. Whether it is in the United States, China, or Rwanda, average human life expectancy has increased over the past few decades. There is growing awareness that increasing longevity will have major implications for how people manage their work lives and careers. Rising life expectancy means the level of savings required to provide a reasonable income for retirement at age 65 is becoming increasingly infeasible for many people. Given the average level of savings, the authors say, many workers in their mid-40s are likely to need to work into their early to mid-70s; many currently in their 20s may work into their late 70s, and even into their 80s. Although people are starting to recognize that they will have to restructure their lives and careers, corporations are unprepared. Few organizations have taken full account of the opportunities and challenges longevity brings to their own workforces. Most companies, especially those operating in the advanced economies, still view life in terms of three stages: full-time education, full-time work, and then a "hard stop"retirement around the age of 65. This is the life structure that emerged in the 20th century and continues to underpin much thinking about the workforce. But in the view of the authors, it cannot be stretched to support a healthy 100-year life and will need to be expanded to include more stages. Without change, the authors argue, employees will struggle to build a working life that has resilience over an extended period of time and that will support a healthy and prosperous longevity. For example, as working lives become longer, the need for lifelong learning will increase.