At EY, Jeff Wong served as chief innovation officer beginning in 2015. In this role, he was responsible for driving innovation and inoculating EY against potential threats to its $45 billion revenue global business. Wong's role advanced and grew with his success in launching initiatives for EY around artificial intelligence, blockchain, Web3, and automation among others. Through it all, Wong built the Global Innovation team at EY from a $5 million budget to hundreds of millions of dollars, returning $5 to $6 to EY for every $1 invested-within a year from when the investment was made.

Align Technologies was a leader in disrupting the orthodontist and dental markets with the original development of clear plastic aligners, which allowed for customized solutions to malocclusions, the incorrect alignment of teeth and jaws. Unlike traditional braces, plastic aligners enabled more flexibility and customization by combining digital and physical technologies that were convenient and attractive than other alternatives. As the company began to enter its third decade, the leadership team was dealing with the challenges of new competition, expiring patents, how to improve international growth and how best to increase operational efficiency.