Human genomics promises to be a wellspring of innovation, diagnosis, and treatment--but it needs an industry cluster if it's to reach its full potential. How and where is such a cluster likely to arise?

The almost universal belief among executives today is that bigger is better: companies are entering into huge, pricey cross-border mergers at an unprecedented rate. Common wisdom is that industries will become more concentrated as they become more global. In this article, the authors debunk the myth of increased concentration; the perceived links between the globalization of an industry and the concentration of that industry are weak. Empirical research shows that global--or globalizing--industries have actually been marked by steady decreases in concentration since World War II. The authors present the biases that managers often have about consolidation and offer alternative strategies to pursuing the big M&A deal. There are better, more profitable ways of dealing with globalization than relentless expansion, they say. Those strategies include buying up cast-off assets from merging rivals; focusing more on domestic or regional growth rather than on global expansion; taking advantage of merging rivals' weakened market position during integration and launching an aggressive marketing campaign; and building alliances with other companies rather than buying them up.