Many people believe that the process for achieving breakthrough innovations is chaotic, random, and unmanageable. But that view is flawed, the authors argue. Breakthroughs can be systematically generated using a process modeled on the principles that drive evolution in nature: "variance generation," which creates a variety of life-forms; and "selection pressure" to select those that can best survive in a given environment. Flagship Pioneering, the venture-creation firm behind Moderna Therapeutics and one of the most widely used Covid-19 vaccines in the United States, uses such an approach. It has successfully launched more than 100 life-sciences businesses. Its process, called "emergent discovery," is a rigorous set of activities including prospecting for ideas in novel spaces; developing speculative conjectures; and relentlessly questioning hypotheses.
The COVID-19 pandemic had forced a production cut in the factory of Sercomm, one of the world's major telecom equipment producers, in China. The case explores and highlights the challenges that Chief Executive Officer James Wang faced: How could Sercomm recover and ramp up production to meet its U.S. clients' immediate demands? In the longer term, how could it manage the increasing shortage of migrant workers in China? As a supplier of hardware components to the U.S., the company was also caught in the cross-fire of U.S.-China trade tensions due to the tariffs imposed on telecom products. Should the company move its production out of China? Could adopting Artificial Intelligence in the production line be an option?
Riccardo Cortese and Federico Pinna were the CEOs of Briscola-Pizza Society, a restaurant chain they had founded in 2014 with a clear ambition: create a distinctive international pizza chain that would combine a fast-casual format with the devotion to quality that characterized family-run Italian restaurants. In 2017, Francesco Trapani, the former CEO of luxury jewelry company Bulgari, had taken a majority stake in the chain, which had switched to a format of "affordable luxury." At the end of 2019, Briscola counted six restaurants in the northern regions of Italy and its founders were grappling with a series of questions: Should they consolidate their position in other Italian regions or expand directly abroad? In which countries would their concept work best? Should they change their direct ownership model? If so, what kinds of partnerships, licensing agreements, and franchise models should they use? Finally, what was the right degree of standardization across their restaurants? Allowing some variations in the menu at the restaurant level would be attractive to target specific segments of their clientele, but would this complicate their operations and potentially hinder their growth?
This case examines the business model and growth of a start-up company in the private aviation industry. In June 2020, amidst the COVID crisis, the company's co-founder and CEO must make a decision regarding an order of new jets that will significantly expand the company's fleet. The case will explore how a company should approach such strategic capacity expansions given significant uncertainty in demand. This can be tied to a broader discussion of the company's overall growth strategy and the scalability of its business model and operating system.
Large established organizations need to innovate as much as small entrepreneurial firms. The problem is, it takes real creativity to build something new out of something old. Harvard Professor and innovation expert Gary Pisano introduces the concept of 'creative construction', which entails redesigning an enterprise in a fundamental way while still operating the core business. He defines four types of innovation that large enterprises should embrace, and argues that all four types likely have a place in every organization's innovation portfolio.
For more than two decades, scientific advances have been driving profound changes in drug discovery and the drug industry itself. This case provides an overview and description of these technical and scientific advances. Written for the nonscientific reader, it may be used as companion reading for other case materials that require basic knowledge of the tools, techniques, and approaches used in the pharmaceutical and biotechnology industries.
This case explores one company's attempt to experiment with a different underlying model for a capitalist enterprise. Brunello Cucinelli, S.p.A. is a leading manufacturer of luxury fashion apparel. Despite being a publicly traded enterprise with annual revenues exceeding 500 million, the company follows a somewhat unique human resource and cultural model. The company's founder, Brunello Cucinelli, has striven to create an enterprise that follows principles of what he calls "humanistic capitalism". Human capitalism, according to Cucinelli, means pursuing growth and profitability in a "gracious way." At the company, humanistic capitalism manifests itself in a very specific set of policies and behavioral norms. Workers are paid wages that exceed 20% of the market norms; the workday (even fore senior executive) is limited to the hours of 8:30 AM to 5:30 PM; emails are not to be sent after hours or on weekends; lunch breaks are one and half hours long to allow workers to have lunch at home should they choose. There are also strong cultural norms emphasizing respect and dignity. As part of this culture, employees are expected to keep their workspaces clean; eating at desks is not permitted; water can only be drunk from cups (not bottles,); speaking should be done in hushed tones so as not to disturb colleagues. None of these cultural norms, however, are explicitly described in any written documents. The company has adopted this model in both its Solomeo, Italy headquarters and in its North American headquarters located in New York City.
Innovative cultures are generally depicted as pretty fun. They're characterized by a tolerance for failure and a willingness to experiment. They're seen as being psychologically safe, highly collaborative, and nonhierarchical. And research suggests that these behaviors translate into better innovative performance. But despite the fact that innovative cultures are desirable, and that most leaders claim to understand what they entail, they are hard to create and sustain. That's because the easy-to-like behaviors that get so much attention are only one side of the coin. They must be counterbalanced by some tougher and frankly less fun behaviors: an intolerance for incompetence, rigorous discipline, brutal candor, a high level of individual accountability, and strong leadership. Unless the tensions created by this paradox are carefully managed, attempts to create an innovative culture will fail.
Flagship Pioneering, located in Cambridge, MA, was founded in 2000 to create ventures focused on solving unprecedented problems in the life sciences. While the company used a venture capital model to raise capital and fund ventures, it was not a venture capital company in the traditional sense. Flagship Pioneering produced and funded its own ventures.
The case examines how Marriott should respond to the potential threats from new home-sharing platforms and the rise of on-line travel agencies. In 2017 Marriott was the largest hotel chain, with more than one million rooms and 7% of worldwide room supply. In the previous decade the growing ubiquity of internet-based commerce had facilitated the rise of technology platforms such as Expedia and Airbnb. The case enables students to explore the forces that might lead to industry transformation and the appropriate response strategies of a large incumbent.
Many people with neurological conditions such as autism spectrum disorder and dyslexia have extraordinary skills, including in pattern recognition, memory, and mathematics. Yet they often struggle to fit the profiles sought by employers. A growing number of companies, including SAP, Hewlett Packard Enterprise, and Microsoft, have reformed their HR processes in order to access neurodiverse talent--and are seeing productivity gains, quality improvement, boosts in innovative capabilities, and increased employee engagement as a result. The programs vary but have seven major elements in common. Companies should: (1) Team with governments or nonprofits experienced in working with people with disabilities; (2) Use noninterview assessment processes; (3) Train other workers and managers in what to expect; (4) Set up a support system; (5) Tailor methods for managing careers; (6) Scale the program; (7) Mainstream the program. The work for managers will be harder, but the payoff to companies will be considerable: access to more of their employees' talents along with diverse perspectives that will help them compete.