Many of the West's political problems in the Middle East and in Iran in particular can be traced to the overthrow of Prime Minister Mohammad Mossadegh by military forces supported by the American CIA and the British MI6 in August 1953. Mossadegh, at the head of a newly-elected nationalist government, had nationalized the Iranian oil industry that had been controlled by the Anglo-Iranian Oil Company (AIOC), now known as BP. Since 1908, the AIOC had been producing enormous revenue for London, and control of Iranian oil was essential to the British Empire. In order to gain Washington's assent to the coup, the Americans had to be convinced that Mossadegh represented a geopolitical threat, not merely an economic one. Ever since, the overthrow of Mossadegh has been seen as evidence of the extent of the supposed neo-imperialist motivations of the West in the post-colonial world.

In the late 1920s and early 1930s when Joseph Stalin, leader of the world's first Communist state, sought to industrialize his largely peasant country on an unprecedented scale, he turned for help to those who had the most experience constructing on such a scale: American businessmen. The ultimate stated purpose of his industrialization program, however, was to end the capitalist system that those businessmen embodied. At the time, the Soviet Union was an international pariah, not recognized by Washington until 1933, surrounded by largely hostile states whose political systems Moscow was trying to subvert in a contest that both sides saw as existential. Despite this, it was American architects and engineers that gave the Soviets the advanced designs and technology they needed to build "socialism in one country," constructing the industrial base that would one day defeat Nazi Germany.

In 1970 Chile became the first country to elect a Marxist president through open, multi-party elections in Salvador Allende. In his first year as president, Allende nationalized the copper industry, Chile's largest export industry that was developed and owned by US multinationals. The nationalization was politically popular, and Allende ultimately refused to provide compensation. The US administration of President Richard Nixon saw Allende's government as a political and ideological threat both in the context of the Cold War, and to the economic interests of the "First World" at a time of rising resource nationalism and political activism in the so-called "Third World."