With the rapid development of digital technologies, many supply chain professionals are wondering how to move forward. Three technologies are poised to change supply chain business processes: robotic process automation (RPA), artificial intelligence (AI), machine learning (ML), and blockchain. Based on interviews with supply chain professionals in 14 large, mature manufacturing and service organizations, we outline the promise of each process and forecast their broad-scale adoption potential. Organizations should take the following measures to ensure their readiness to adopt and effectively use one or more of these technologies: (1) identify a supply chain technology visionary who can lead through the maze of technologies and the changing digital landscape, (2) develop a digital technology roadmap for their supply chain processes, and (3) update foundational information systems.